Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol

Table 3

βLAP solubility (mg·mL⁻¹) and enhancement factor (EF) in F127 and in P123 systems at 4°C with and without 5% (w/v) RMβCD and 20% (v/v) ethanol: mean values and, in parenthesis, the standard deviations.

		Without additives		+ ethanol		+ RMβCD
Pluronic %		[βLAP]	EF	[βLAP]	EF	[βLAP]	EF
F127	18%	0.248 (0.032)	8.3	0.660 (0.051)	22.0	1.037 (0.141)	34.6
	23%	0.444 (0.108)	14.8	1.183 (0.102)	34.4	1.487 (0.117)	49.6
	28%	0.208 (0.028)	7.0	—	—	0.767 (0.141)	25.6
P123	28%	0.875 (0.209)	29.2	2.372 (0.385)	79.1	1.478 (0.383)	49.3