Network Analysis of Functional Genomics Data: Application to Avian Sex-Biased Gene Expression
Example of sex-differentiation-driven subfunctionalization. The chicken genes GSTA2 and GSTA3 (glutathione S-transferases 2 and 3; shown as diamonds) originate from a duplication that happened after the divergence from human, making them inparalogs. GSTA2 is male biased, but GSTA3 is female biased in the adult gonad. Their interaction partners in the chicken network are shown with sex bias. Male-biased genes are shown in blue, female-biased in red, unbiased in green, and unknown in grey.