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The Scientific World Journal
Volume 2012 (2012), Article ID 141240, 15 pages
http://dx.doi.org/10.1100/2012/141240
Research Article

Plasmalogens Inhibit APP Processing by Directly Affecting γ-Secretase Activity in Alzheimer’s Disease

1Experimental Neurology, Saarland University, Kirrbergerstraβe, 66421 Homburg/Saar, Germany
2Psychiatry, Saarland University, Kirrbergerstraβe, 66421 Homburg/Saar, Germany
3Deutsches Institut für DemenzPrävention (DIDP), Universität des Saarlandes, Kirrbergerstraβe, 66421 Homburg/Saar, Germany
4Neurodegeneration and Neurobiology, Saarland University, Kirrbergerstraβe, 66421 Homburg/Saar, Germany

Received 10 October 2011; Accepted 30 November 2011

Academic Editor: Dietmar R. Thal

Copyright © 2012 Tatjana L. Rothhaar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplemental information contains the cytotoxicity measurements after PC-PL and PE-PL incubation. Further, specificity controls of secretase assays for α-, β- and γ-secretase were presented. All methods used in the supplemental information are described in the Material and Method section within the manuscript.

  1. Supplementary Material