Plasmalogens Inhibit APP Processing by Directly Affecting γ-Secretase Activity in Alzheimer’s Disease

Table 2

Analyzed PC-PL and PE-PL species in human AD postmortem brains compared to healthy individuals. Levels of all analyzed PC-PL and PE-PL species were reduced in human AD postmortem brains. Statistical significance was determined by two-tailed Students t-test. SEM = standard deviation of the mean.

Metabolite	% (compared to control)	SEM	t-test
PC-PL 16 : 0/18 : 1 (PC-PL 34 : 1)	64,55	1,654	0,0011
PC-PL 18 : 0/18 : 1 (PC-PL 36 : 1)	68,93	1,814	0,0005
PC-PL 18 : 1/18 : 1 (PC-PL 36 : 2)	49,17	1,452	0,0007
PC-PL 16 : 0/20 : 4 (PC-PL 36 : 4)	81,56	2,681	0,0483
PC-PL 18 : 0/20 : 4 (PC-PL 38 : 4)	85,02	1,930	0,0051
PC-PL 18 : 1/20 : 4 (PC-PL 38 : 5)	84,58	3,744	0,1105
PC-PL 16 : 0/22 : 6 (PC-PL 38 : 6)	88,21	2,925	0,0735
PC-PL 18 : 0/22 : 6 (PC-PL 40 : 6)	88,99	2,388	0,0184
PE-PL 18 : 1/18 : 1 (PE-PL 36 : 2)	83,18	7,252	0,2152
PE-PL 16 : 0/20 : 4 (PE-PL 36 : 4)	78,67	7,181	0,1631
PE-PL 18 : 0/20 : 4 (PE-PL 38 : 4)	80,55	6,795	0,1540
PE-PL 18 : 1/20 : 4 (PE-PL 38 : 5)	93,96	6,194	0,5656
PE-PL 16 : 0/22 : 6 (PE-PL 38 : 6)	94,07	6,250	0,5752
PE-PL 18 : 0/22 : 6 (PE-PL 40 : 6)	86,24	5,190	0,2049