The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients
Table 2
Comparison of the baseline laboratory parameters among all study patients, initial responders (IR), the rest of the study patients (Non IR), sustained responders (SR) and the rest of the study patients (Non-SR) after treatment of CERA.
Case number
All ()
IR ()
Non-IR ()
SR ()
Non-SR ()
WBC count (103/mm3)
6200 (5250–7300)
5750 (4925–6675)
6500 (5250–7350)
5750 (4850–6100)
6600 (5300–7350)
RBC count (106/mm3)
3.39 ± 0.38
3.35 ± 0.37
3.41 ± 0.38
3.34 ± 0.22
3.41 ± 0.40
Hct (%)
31.78 ± 4.15
31.99 ± 3.73
31.71 ± 4.33
32.70 ± 2.27
31.56 ± 4.48
Platelet count (103/μL)*
179.21 ± 50.64
162.31 ± 34.93
185.22 ± 54.23
180.00 ± 55.10
179.02 ± 50.10
Iron (μg/dL)
57.39 ± 25.95
67.81 ± 36.50
53.69 ± 20.27
50.25 ± 14.31
59.14 ± 27.91
TIBC (μg/dL)
209.33 ± 36.83
213.69 ± 39.56
207.78 ± 36.16
207.67 ± 31.61
209.73 ± 38.30
TSAT (%)
28 ± 14
32 ± 20
26 ± 11
24± 6
29 ± 15
Ferritin (ng/mL)*
371 (224.5–578.5)
475 (315.5–820.5)
361 (204.5–543.5)
353 (240.75–460)
375 (220–596)
Total protein (g/dL)*
6.82 ± 0.54
7.03 ± 0.56
6.74 ± 0.52
6.90 ± 0.60
6.80 ± 0.53
Albumin (g/dL)
3.93 ± 0.38
4.08 ± 0.29
3.87 ± 0.40
3.93 ± 0.34
3.93 ± 0.39
Total cholesterol (mg/dL)
184.88 ± 49.90
199.14 ± 50.16
174.90 ± 49.81
156.25 ± 59.83
193.69 ± 45.48
Triglyceride (mg/dL)
119.5 (75.00–213.75)
133 (81.00–230.00)
103 (70.50–200.00)
130.5 (78.75–213.75)
119.5 (71.25–213.50)
Uric acid (mg/dL)
8.17 ± 1.10
8.30 ± 1.17
8.08 ± 1.11
7.33 ± 1.27
8.43 ± 0.95
HDL (mg/dL)
45.93 ± 19.99
46.31 ± 15.49
45.79 ± 21.62
43.27 ± 12.40
46.55 ± 21.43
LDL (mg/dL)+
101.34 ± 42.399
98.13 ± 44.17
102.57 ± 42.19
79.45 ± 23.45
106.47 ± 44.35
Glucose (mg/dL)
156.18 ± 89.89
135.44 ± 76.78
163.56 ± 93.79
130.00 ± 92.84
162.59 ± 88.95
BUN (mg/dL)
75.79 ± 21.54
80.63 ± 27.13
74.07 ± 19.24
75.25 ± 25.26
75.92 ± 20.82
Cr (mg/dL)
11.14 ± 2.38
11.52 ± 1.96
11.01 ± 2.52
10.97 ± 2.42
11.19 ± 2.39
Na (mmol/L)*
136.43 ± 3.81
138.25 ± 3.91
135.78 ± 3.59
136.92 ± 3.40
136.31 ± 3.92
K (mmol/L)
4.7 ± 0.61
4.72 ± 0.60
4.70 ± 0.625
4.68 ± 0.55
4.71 ± 0.63
Cl (mmol/L)
95.84 ± 4.07
97.06 ± 4.57
95.40 ± 3.84
95.92 ± 2.27
95.82 ± 4.42
Ca (mg/dL)
9.49 ± 0.91
9.58 ± 0.85
9.46 ± 0.94
9.51 ± 0.74
9.49 ± 0.96
P (mg/dL)
4.62 ± 1.52
4.64 ± 1.53
4.62 ± 1.53
4.18 ± 1.18
4.73 ± 1.58
iPTH (pg/mL)
109.00 (50.08–277.00)
180.50 (94.27–381.75)
91.43 (41.13–179.00)
85.16 (28.92–269.00)
121.50 (53.48–293.50)
T.bili (mg/dL)*
0.23 ± 0.11
0.28 ± 0.139
0.21 ±.099
0.24 ± 0.16
0.23 ± 0.10
ALK-P (U/L)
82.59 ± 28.39
82.43 ± 25.86
82.70 ± 31.41
97.25 ± 21.08
78.08 ± 29.49
GGT (U/L)
17.00 (17.00–27.00)
18.50 (12.25–26.50)
17.00 (13.00–28.50)
21.50 (16.25–31.25)
17.00 (12.00–27.00)
ALT (U/L)
16.92 ± 8.19
17.38 ± 7.89
16.76 ± 8.38
20.92 ± 14.11
15.94 ± 5.77
AST (U/L)
16.82 ± 8.09
16.06 ± 6.59
17.09 ± 8.61
19.67 ± 12.76
16.12 ± 6.48
CRP (mg/dL)+
1.41 (0.31–3.90)
2.23 (0.31–7.63)
0.90 (0.30–2.34)
0.90 (0.18–2.58)
1.57 (0.31–4.19)
(* for the comparison between IR and non-IR; + between SR and non-SR). WBC, white blood cell; RBC, red blood cell; Hct, hematocrit; TIBC, total iron-binding capacity; TSAT, transferrin saturation; HDL, high-density lipoprotein; LDL, low-density lipoprotein; BUN, blood urea nitrogen; Cr, creatinine; Na, sodium; K, potassium; Cl, chloride; Ca, calcium; P, phosphate; iPTH, serum intact parathyroid hormone; T. bili, total bilirubin; ALK-P, alkaline phosphatase; GGT, γ-glutamyl transferase; ALT, alanine transaminase; AST, aspartate transaminase; CRP, C-reactive protein).
