Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period
Change in JKOM score with respect to subject’s age. Subjects were divided into two groups of younger (≦70 years of age; 21 subjects) and older subjects (older than 70 years of age; 17 subjects), and change of JKOM score was evaluated in the respective groups. For younger subjects, change rate of total score relative to that at baseline (a) is shown together with rates for “pain and stiffness in the knees” (b), “condition of daily life” (c), “general activities” (d), and “health conditions” subscales (e). Change rates of total JKOM score and those of 4 subscales for older subjects are shown in the same manner (f–j, resp.). Open and closed circles indicate change rates of subjects given HA and placebo, respectively. Results are mean ± SE of 7 to 11 subjects. against baseline and against placebo group.
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