Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

Table 1

Demographic and clinical characteristics of subjects at enrollment.

	HA	Placebo
Number of subjects	30	30
Male	7	7
Female	23	23
Age	69 ± 1	69 ± 1
JKOM score
Total	43 ± 2	46 ± 3
Subscales
Pain and stiffness in knees	15 ± 1	16 ± 1
Condition in daily life	16 ± 1	17 ± 1
General activities	8 ± 1	9 ± 1
Health conditions	4 ± 0	4 ± 0
Kellgren and Lawrence grade
Grade 2	13	13
Grade 3	17	17
Additional medication
NSAID, oral administration	8	9
NSAID, external use	16	15
HA, intra-articular injection	23	28

Results are mean ± SE.