Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period
Table 2
Change of JKOM score during study period.
Time (month)
0
2
4
6
12
Total
HA
100.0 ± 0.0
80.6 ± 3.1*
71.8 ± 3.0*
72.4 ± 3.5*
70.9 ± 3.9*
Placebo
100.0 ± 0.0
87.4 ± 3.1*
78.9 ± 3.1*
74.8 ± 3.2*
72.1 ± 4.0*
Subscale
Pain and stiffness in knees
HA
100.0 ± 0.0
77.0 ± 3.6*
70.2 ± 3.7*
73.7 ± 4.2*
66.8 ± 4.4*
Placebo
100.0 ± 0.0
84.6 ± 4.6*
76.5 ± 3.9*
71.8 ± 4.0*
72.5 ± 8.0*
Condition in daily life
HA
100.0 ± 0.0
83.7 ± 3.8*
77.6 ± 3.9*
77.0 ± 4.1*
76.2 ± 4.4*
Placebo
100.0 ± 0.0
89.2 ± 3.7*
83.9 ± 4.1*
81.3 ± 3.5*
76.0 ± 3.4*
General activities
HA
100.0 ± 0.0
94.2 ± 7.4
75.5 ± 4.8*
73.3 ± 5.0*
81.1 ± 5.8*
Placebo
100.0 ± 0.0
92.5 ± 4.9
80.3 ± 5.8*
73.4 ± 4.8*
72.8 ± 4.1*
Health condition
HA
100.0 ± 0.0
74.0 ± 6.0*#
64.6 ± 7.7*#
63.0 ± 6.1*#
60.9 ± 5.6*#
Placebo
100.0 ± 0.0
96.1 ± 8.2
91.1 ± 9.9
88.3 ± 10.1*
81.2 ± 6.0*
Results are shown by relative rations (in percent) against scores at baseline. Mean ± SE of 18 (HA group) or 20 (placebo group) subjects are shown. *P < 0.05 against baseline; #P< 0.05 against placebo group.
