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The Scientific World Journal
Volume 2012 (2012), Article ID 174784, 8 pages
http://dx.doi.org/10.1100/2012/174784
Research Article

An Efficient Protocol for the Synthesis of Quinoxaline Derivatives at Room Temperature Using Recyclable Alumina-Supported Heteropolyoxometalates

1Cátedra de Química Orgánica, Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata, Calles 60 y 119, La Plata B1904AAN, Argentina
2Facultad Regional San Nicolás, Universidad Tecnológica Nacional (UTN), Colón N-332, San Nicolás, Buenos Aires 2900, Argentina
3Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. J.J. Ronco” (CINDECA), Departamento de Química, Facultad de Ciencias Exactas, UNLP-CCT-CONICET, Calles 47 No. 257, La Plata B1900AJK, Argentina

Received 6 October 2011; Accepted 13 November 2011

Academic Editors: K. Abouzid and H. Amri

Copyright © 2012 Diego M. Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a suitable quinoxaline synthesis using molybdophosphovanadates supported on commercial alumina cylinders as catalysts. These catalysts were prepared by incipient wetness impregnation. The catalytic test was performed under different reaction conditions in order to know the performance of the synthesized catalysts. The method shows high yields of quinoxaline derivatives under heterogeneous conditions. Quinoxaline formation was obtained using benzyl, o-phenylenediamine, and toluene as reaction solvent at room temperature. The CuH2PMo11VO40 supported on alumina showed higher activity in the tested reaction. Finally, various quinoxalines were prepared under mild conditions and with excellent yields.