Angiotensins Inhibit Cell Growth in GH3 Lactosomatotroph Pituitary Tumor Cell Culture: A Possible Involvement of the p44/42 and p38 MAPK Pathways

Figure 7

The influence of p44/42 MAPK inhibitor PD98059 at concentration 10⁻⁵ M on angiotensin-II-(AII-) and angiotensin-5–8-(A5–8-) induced decrease of the BrdU incorporation into lactosomatotroph GH3 cells. 𝑋 axis: absolute values of the optical density (OD), auxiliary axis (▲): OD in the particular groups expressed as the percentage of the optical density measured at 450 nm of unstimulated cells (control (C) = 100%). 𝑋 ± SEM; *𝑃<0.05 versus C, **𝑃<0.05 versus AII, ***𝑃<0.05 versus A5–8.