The c.1460C>T Polymorphism of MAO-A Is Associated with the Risk of Depression in Postmenopausal Women

Table 1

The genotype distribution between postmenopausal women with (𝑤) and without (𝑤/𝑜) depression.

Polymorphism	𝑛	Genotype and allele distribution absolute number (frequency)					Allele 𝑃 Value	Genotype; Odds ratio (95% CI); 𝑃 Value
		CC	CT	TT	C	T
5HTR2A c. 102C>T (SNP 6313)	w depression	50	44	19	144	82	𝑃=0.735	0.769 (0.485–1.219)^a; 𝑃=0.2634^b
	Total 113	(0.44)	(0.39)	(0.17)	(0.64)	(0.36)
	w/o depression	83	107	29	273	165
	Total 219	(0.38)	(0.49)	(0.13)	(0.62)	(0.38)
		GG	GC	𝐂𝐂	G	C
5HTR1B c.861G>C (SNP 6296)	w depression	62	44	7	168	58	𝑃=0.635	1.094 (0.693–1.728)^a; 𝑃=0.700^b
	Total 113	(0.55)	(0.39)	(0.06)	(0.74)	(0.26)
	w/o depression	125	83	11	333	105
	Total 219	(0.57)	(0.38)	(0.05)	(0.76)	(0.24) )
		GG	GC	𝐂𝐂	G	C		0.996 (0.610–1.628)^a; 𝑃=0.989^b
5HTR2C c. 68G>C (SNP 6318)	w depression	78	30	5	186	40	𝑃=1.000
	Total 113	(0.69)	(0.27)	(0.04)	(0.82)	(0.18)
	w/o depression	151	57	11	359	79
	Total 219	(0.69)	(0.26)	(0.05)	(0.82)	(0.18) )
		CC	CT	TT	C	T		1.772 (1.112–2.825)^a; 𝑃=0.0198^*b
MAO-A c.1460C>T (SNP 1137070)	w depression	41	56	16	138	88	𝑃=0.011 *
	Total 113	(0.36)	(0.50)	(0.14)	(0.61)	(0.39)
	w/o depression	110	91	18	311	127
	Total 219	(0.50)	(0.42)	(0.08)	(0.71)	(0.29) )
		CC	CA	AA	C	A
TPH1 218C>A (SNP 1800532)	w depression	44	49	20	137	89	𝑃=0.801	1.014 (0.637–1.615)^a; 𝑃=0.9533^b
	Total 113	(0.39)	(0.43)	(0.18)	(0.61)	(0.39)
	w/o depression	86	99	34	271	167
	Total 219	(0.39)	(0.45)	(0.16)	(0.62)	(0.38) )
		GG	GA	AA	G	A
TPH2 c.1077G>A (SNP 7305115)	w depression	45	51	17	141	85	𝑃=0.737	0.870 (0.546–1.386)^a; 𝑃=0.5573^b
	Total 113	(0.40)	(0.45)	(0.15)	(0.62)	(0.38)
	w/o depression	80	106	33	266	172
	Total 219	(0.37)	(0.48)	(0.15)	(0.61)	(0.39)

The women’s groups were classified based on the severity of depression assessed by the Hamilton rating scale for depression: w/o depression (0–7), mild depression (8–17), and moderate depression (18–25). The 113 women with depression included 82 women with mild depression and 31 women with moderate depression.
^aThe Odds Ratio was calculated for patients homozygous or heterozygous carrying risk allele vs. homozygous.
^bFisher exact test was used for comparison of patients with depression versus patients without depression.