Genomic Profiling of a Human Leukemic Monocytic Cell-Line (THP-1) Exposed to Alpha Particle Radiation

Table 1

Expression profile of genes that were shown to be statistically significant (a) 24 h and (b) 72 h following alpha-particle irradiation at all doses using microarray analysis. Statistics based on an 𝑛=5 biological replicates.

(a) 24 h

	0.5 Gy	1.0 Gy	1.5 Gy
Number of Transcripts	38	84	163
Common Amongst All Doses (%)	15 (39)	15 (18)	15 (9)
Exclusive (%)	13 (34)	10 (12)	87 (53)
Upregulated (%)	38 (100)	81 (96)	147 (30)
Common Amongst All Doses (%)	15 (39)	15 (18)	15 (51)
Exclusive (%)	13 (34)	10 (5)	74 (18)
Downregulated (%)	N/A (0)	3(4)	16 (10)
Common Amongst All Doses (%)	N/A	3 (100)	3 (19)
Exclusive (%)	N/A	0 (0)	13 (81)

(b) 72 h

	0.5 Gy	1.0 Gy	1.5 Gy
Number of Transcripts	143	152	190
Common Amongst All Doses (%)	47 (33)	47 (31)	47 (25)
Exclusive (%)	82 (57)	25 (16)	57 (30)
Upregulated (%)	110 (77)	24 (16)	50 (26)
Common Amongst All Doses (%)	15 (14)	15 (63)	15 (8)
Exclusive (%)	82 (75)	2 (8)	23 (12)
Downregulated (%)	33 (23)	128 (84)	140 (74)
Common Amongst All Doses (%)	32 (97)	32 (25)	32 (23)
Exclusive (%)	1 (3)	23 (18)	34 (24)