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The Scientific World Journal
Volume 2012, Article ID 206350, 7 pages
http://dx.doi.org/10.1100/2012/206350
Clinical Study

Incidence and Survival of Patients with Small Intestinal Neuroendocrine Tumours in a Danish NET Center

Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, 8000 Aarhus, Denmark

Received 12 October 2012; Accepted 31 October 2012

Academic Editors: S.-N. Lu and L. Roncucci

Copyright © 2012 Lise Brehm Hoej et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Small intestinal neuroendocrine tumours (NETs) have increased in incidence during the past decades. In recent years, new promising treatment modalities have been introduced. The aim of the present study was to characterize and compare patients with small intestinal NET seen in the periods 1994–2003 (group 1) and 2004–2011 (group 2) to demonstrate changes in incidence and survival in the two time periods. Patients and Methods. There were 52 NET patients in group 1 and 109 patients in group 2. Results. The incidence of small intestinal NET was 0.3/100.000/year in period 1 and 0.7/100.000/year in period 2. There was no difference in median chromogranin A levels (8709 versus 2381 pmol/L, ), presence of liver metastases (56% versus 44%), clinical symptoms (flushing/diarrhea), or Ki67 index (2% versus 2%), between the two time periods. The 5-year survival rate in the two time periods was similar, 64.7%, and 77.0%, respectively, ( ). Conclusion. We observed an increase in the incidence of small intestinal NET during the period from January 1994 to December 2011, but we were not able to demonstrate an improved survival during the same time period.