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The Scientific World Journal
Volume 2012, Article ID 219082, 7 pages
Research Article

Effect of Dietary Supplements in Reducing Probability of Death for Uremic Crises in Dogs Affected by Chronic Kidney Disease (Masked RCCT)

1Clinica Veterinaria Pirani, Nephrology and Urology Division, Via Majakowski 2/L,M,N, 42124 Reggio Emilia, Italy
2Istituto Farmaceutico Candioli, Via Manzoni 2, 10192 Beinasco, Italy
3Istituto Veterinario di Novara, S.P. 9, 28060 Granozzo con Monticello, Italy
4Department of Veterinary Clinical Sciences, University of Padua, 35020 Agripolis, Legnaro, Italy

Received 14 October 2011; Accepted 8 December 2011

Academic Editor: Jiannong Liu

Copyright © 2012 Andrea Zatelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chitosan and alkalinizing agents can decrease morbidity and mortality in humans with chronic kidney disease (CKD). Whether this holds true in dog is not known. Objective of the study was to determine whether a commercial dietary supplement containing chitosan, phosphate binders, and alkalinizing agents (Renal), compared to placebo, reduces mortality rate due to uremic crises in dogs with spontaneous CKD, fed a renal diet (RD). A masked RCCT was performed including 31 azotemic dogs with spontaneous CKD. Dogs enrolled in the study were randomly allocated to receive RD plus placebo (group A; 15 dogs) or RD plus Renal (group B; 16 dogs). During a first 4-week period, all dogs were fed an RD and then randomized and clinically evaluated up to 44 weeks. The effects of dietary supplements on mortality rate due to uremic crises were assessed. At 44 weeks, compared to group A, dogs in group B had approximately 50% lower mortality rate due to uremic crises ( 𝑃 = 0 . 0 1 5 ). Dietary supplementation with chitosan, phosphate binders, and alkalinizing agents, along with an RD, is beneficial in reducing mortality rate in dogs with spontaneous CKD.