Protection of the Extracts of Lentinus edodes Mycelia against Carbon-Tetrachloride-Induced Hepatic Injury in Rats

Figure 3

Effects of LEM on activities of hepatic Mn-SOD, Cu/Zn-SOD, and glutathione peroxidase (GPx) in CCl₄-treated rats. (a) Changes of hepatic Mn-SOD by oral administration of LEM in CCl₄-treated rats for 8 weeks. (b) Changes of hepatic Cu/Zn-SOD by oral administration of LEM in CCl₄-treated rats for 8 weeks. (c) Changes of hepatic GPx by oral administration of LEM in CCl₄-treated rats for 8 weeks. Lane 1: vehicle-treated Wistar rats; lane 2: vehicle-treated CCl₄-induced rats; lane 3: silymarin- (200 mg/kg) treated CCl₄-induced rats; lane 4: LEM- (100 mg/kg) treated CCl₄-induced rats; lane 5: LEM- (200 mg/kg) treated CCl₄-induced rats; lane 6: LEM- (500 mg/kg) treated CCl₄-induced rats. Data represent mean ± SEM of eight animals. *𝑃<0.05 and **𝑃<0.01 compared with CCl₄-induced group receiving vehicle.

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