The Study of Release of Chlorhexidine from Preparations with Modified Thermosensitive Poly-N-isopropylacrylamide Microspheres

Table 3

Release rates of CX from polymeric preparations.

Polymer	Release rates assessed at 22°C (min^−1)				Release rates assessed at 37°C (min^−1)
	1st stage	SD	2nd stage	SD	1st stage	SD	2nd stage	SD
pNIPAM-A-CX	2.85×10^−3	0.01×10^−3	1.74×10^−3	0.02×10^−3	4.98×10^−3	0.02×10^−3	2.80×10^−3	0.26×10^−3
pNIPAM-B-CX	2.62×10^−3	0.02×10^−3	2.15×10^−3	0.05×10^−3	4.79×10^−3	0.04×10^−3	2.50×10^−3	0.18×10^−3
pNIPAM-C-CX	7.43×10^−3	0.04×10^−3	7.57×10^−4	0.40×10^−4	5.37×10^−3	0.04×10^−3	5.26×10^−3	0.39×10^−3
MC-CX	1.66×10^−3	0.03×10^−3	—	—	1.22×10^−2	0.01×10^−2	—	—
PA-CX	3.60×10^−5	0.04×10^−5	—	—	4.09×10^−5	0.05×10^−5	—	—
H2O-CX	3.29×10^−3	0.07×10^−3	—	—	1.06×10^−2	0.03×10^−2	—	—

pNIPAM-A-CX, pNIPAM-B-CX, pNIPAM-C-CX: preparations of respective polymers detailed in the text with chlorhexidine, MC-CX: preparation of methylcellulose and chlorhexidine, PA-CX: preparation of polyacrylic acid and chlorhexidine, and H₂O-CX: aqueous dispersion of chlorhexidine, data from repeated six experiments.