Serial MRI Features of Canine GM1 Gangliosidosis: A Possible Imaging Biomarker for Diagnosis and Progression of the Disease

Figure 1

Various transverse sections of T2W and FLAIR images at 2 (A: age-matched control dog (control) and B: affected laboratory dog (model)) or 3 months of age (C: clinical case 1 (animal 1)). T2W hyperintensity in the subcortical white matter of the whole cerebrum was observed in affected dogs (B, C), but almost nonexistent in the control dog (A). T2W hyperintensity was more clearly recognized in B, which was obtained by a 1.5 Tesla system, than in C, which was obtained by a 0.3 Tesla system. In addition, subcortical hyperintensity was difficult to detect on the FLAIR images obtained by a 0.3 Tesla system.