Serial MRI Features of Canine GM1 Gangliosidosis: A Possible Imaging Biomarker for Diagnosis and Progression of the Disease

<table>Serial changes in affected dogs (transverse T2W images at the thalamus/3rd ventricle level). Subcortical T2W hyperintensity was consistently observed at any timepoint. T2W hypointensity in the internal capsule was also recognized in the affected laboratory animal (model). Atrophic changes, which were indicated by ventricular enlargement and well-demarcated sulci, were observed in all affected dogs (model and animals 1–3) from 8 to 9 months of age.</table>

The Scientific World Journal

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Figure 2: Serial MRI Features of Canine GM1 Gangliosidosis: A Possible Imaging Biomarker for Diagnosis and Progression of the Disease 