Serial MRI Features of Canine GM1 Gangliosidosis: A Possible Imaging Biomarker for Diagnosis and Progression of the Disease
Figure 5
Changes in brain volumetry (a) and interthalamic adhesion thickness (b). Brain volume of the control dog (control) reached a steady volume at 3–5 months of age, whereas that of the affected dog (model) increased gradually until 8 months and then started to decrease. Similar changes were also found in interthalamic adhesion thickness.