Serial MRI Features of Canine GM1 Gangliosidosis: A Possible Imaging Biomarker for Diagnosis and Progression of the Disease
Figure 6
Histological findings in the affected laboratory dog. (a) High magnification of hematoxylin and eosin stain. Markedly swollen neurons filled with the storage materials were found throughout the central nervous system. Bar = 50 μm. (b) Anti-MBP immunohistochemistry of the cerebrum in an 11-month-old affected dog and (c) a 2-year-old control mixed-breed dog. Poor myelination was particularly detected in the subcortical white matter in the affected dog compared with that in the control dogs. SCWM: subcortical white matter, DWH: deep white matter. Bar = 1 mm.
