Morphology of the Myoepithelial Cell: Immunohistochemical Characterization from Resting to Motile Phase

Table 2

Immunohistochemical results for suprabasal and motile myoepithelial cells.

Type of lesion	Cell morphology					Antibodies for^*
			p63	CK14	CK5/6	CK19	Alpha-SMA	VIM	ER
Normal mammary gland (𝑛=3)^°	Suprabasal	resting	++	++	+	−	++	++	+
		proliferative	++	+	+	−	++	++	+
Mammary tissue in the same tumor line (𝑛=29)^°	Suprabasal	resting	++	++	++	−	++	++	+(12/29)
		proliferative	++	+	+	−	++	++	+(12/29)
Benign myoepithelioma (𝑛=3)^§	Motile	spindle	−	±(2/3)	−	−	−	++	−
		stellate	−	−	−	−	−	++	−
Malignant myoepithelioma (𝑛=3)^§	Motile	spindle	−	±	−	−	−	++	−
		stellate	−	−	−	−	−	++	−
Carcinoma in benign-mixed tumor (𝑛=7)	Suprabasal	resting	++	++	+(5/7)	−	++	++	+(4/7)
		proliferative	++	+/±(2/7)	+(3/7)	−	++	++	+(4/7)
	Motile	spindle	−	±(2/7)	+(3/7)	−	±(5/7)	++	+(3/7)
		stellate	−	−	−	−	−	++	+(3/7)
Complex carcinoma (𝑛=16)	Suprabasal	resting	++	++(15/16)	+(11/16)	−	++	++	+(7/16)
		proliferative	++	+(15/16)	+(7/16)	−	++	++	+(7/16)
	Motile	spindle	−	±(2/16)	+(7/16)	−	±(5/16)	++	+(6/16)
		stellate	−	−	−	−	±(2/16)	++	+(6/16)

^*−: no stained cells; ±: less than 5% positive cells; +: 5–50% positive cells; ++: more than 50% positive cells.
^°: the motile phonotype is not updated because not present.
^§: the suprabasal phonotype is not updated because not detectable around luminal cells.