Research Article
In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates
Table 1
Antibacterial activity of benzoates 1-18.
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| | MIC/IC80 [μmol/L] | |
R1 |
R2 | Staphylococcus aureus | MRSA S. aureus | Staphylococcus epidermidis | Enterococcus sp. | Pseudomonas aeruginosa | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h |
| (1) | 4-Cl | 3-Cl | 0.98 | 3.9 | 0.98 | 3.9 | 1.95 | 7.81 | 31.25 | 62.5 | 3.9 | 7.81 | (2) | 5-Cl | 3-Cl | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 62.5 | >125 | >125 | >125 | >125 | (3) | 4-Cl | 4-Cl | 3.9 | 3.9 | 3.9 | 3.9 | >125 | >125 | >125 | >125 | >125 | >125 | (4) | 5-Cl | 4-Cl | 15.62 | 31.25 | 15.62 | 31.25 | 31.25 | 31.25 | >125 | >125 | >125 | >125 | (5) | 4-Cl | 3,4-diCl | 1.95 | 3.9 | 1.95 | 7.81 | 1.95 | 1.95 | 1.95 | 1.95 | >125 | >125 | (6) | 5-Cl | 3,4-diCl | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | >125 | >125 | (7) | 4-Cl | 3-Br | 3.9 | 7.81 | 3.9 | 7.81 | 1.95 | 3.9 | 7.81 | >125 | >125 | >125 | (8) | 5-Cl | 3-Br | 1.95 | 3.9 | 3.9 | 7.81 | 1.95 | 3.9 | 7.81 | >125 | >125 | >125 | (9) | 4-Cl | 4-Br | 1.95 | 7.81 | 7.81 | 15.62 | 3.9 | 15.62 | 125 | >125 | >125 | >125 | (10) | 5-Cl | 4-Br | 62.5 | >125 | 125 | >125 | 15.62 | >125 | >125 | >125 | >125 | >125 | (11) | 4-Cl | 3-F | 3.9 | 7.81 | 3.9 | 7.81 | 1.95 | 7.81 | 31.25 | >125 | >125 | >125 | (12) | 5-Cl | 3-F | 3.9 | 7.81 | 3.9 | 15.62 | 1.95 | 7.81 | 7.81 | >125 | >125 | >125 | (13) | 4-Cl | 4-F | 7.81 | 7.81 | 15.62 | 15.62 | 1.95 | 3.9 | 62.5 | >125 | >125 | >125 | (14) | 5-Cl | 4-F | 3.9 | 7.81 | 7.81 | 15.62 | 1.95 | 3.9 | >125 | >125 | >125 | >125 | (15) | 4-Cl | 4-CF3 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | >125 | >125 | (16) | 5-Cl | 4-CF3 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | 3.9 | >125 | >125 | >125 | >125 | (17) | 4-Cl | 3-CF3 | 1.95 | 3.9 | 1.95 | 7.81 | 1.95 | 3.9 | 7.81 | >125 | >125 | >125 | (18) | 4-Br | 4-CF3 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | 1.95 | >125 | >125 | >125 | PNC | — | — | 0.98 | 0.98 | 62.5 | 125 | 250 | 250 | 7.81 | 15.62 | >500 | >500 | BA | — | — | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 |
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PNC: penicillin G; BA: benzoic acid. The lowest MIC value(s) for each strain are bolded.
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