Research Article
Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
Table 2
ICRS Visual Histological Assessment Scale (modified by Mainil-Varlet, 2003) [
15].
| Feature | Score |
| H&E | | (I) Surface | | Smooth/continuous | 3 | Discontinuities/irregularities | 0 | (II) Matrix | | Hyaline | 3 | Mixture: hyaline/fibrocartilage | 2 | Fibrocartilage | 1 | Fibrous tissue | 0 | (III) Cell distribution | | Columnar | 3 | Mixed/columnar clusters | 2 | Clusters | 1 | Individual cells/disorganized | 0 | (IV) Cell population viability | | Predominantly viable | 3 | Partially viable | 1 | <10% viable | 0 | (V) Subchondral bone | | Normal | 3 | Increased remodeling | 2 | Bone necrosis/granulation tissue | 1 | Detached/fracture/callus at base | 0 | (VI) Cartilage mineralization (calcified cartilage) | | Normal | 3 | Abnormal/inappropriate location | 0 | PCNA | | Positive | 3 | Negative | 0 | Collagen type I | | Abundant | 3 | Little | 1 | No | 0 | Collagen type II | | Abundant | 3 | Little | 1 | No | 0 |
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