The Scientific World Journal

Research Article

Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits

Table 2

ICRS Visual Histological Assessment Scale (modified by Mainil-Varlet, 2003) [15].
FeatureScore
H&E
 (I) Surface
   Smooth/continuous3
   Discontinuities/irregularities0
  (II) Matrix
   Hyaline3
   Mixture: hyaline/fibrocartilage2
   Fibrocartilage1
   Fibrous tissue0
  (III) Cell distribution
   Columnar3
   Mixed/columnar clusters2
   Clusters1
   Individual cells/disorganized0
  (IV) Cell population viability
   Predominantly viable3
   Partially viable1
   <10% viable0
  (V) Subchondral bone
   Normal3
   Increased remodeling2
   Bone necrosis/granulation tissue1
   Detached/fracture/callus at base0
  (VI) Cartilage mineralization (calcified cartilage)
   Normal3
   Abnormal/inappropriate location0
PCNA
  Positive3
  Negative0
Collagen type I
  Abundant3
  Little1
  No0
Collagen type II
  Abundant3
  Little1
  No0