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The Scientific World Journal
Volume 2012, Article ID 327071, 9 pages
http://dx.doi.org/10.1100/2012/327071
Research Article

Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat

1Departamento de Farmacologia, Faculdade de Ciências Médicas, UNICAMP, 13083-970 Campinas, SP, Brazil
2Departamento de Fisiologia e Biofísica, Instituto de Biologia, UNICAMP, 13083-970 Campinas, SP, Brazil
3Departamento de Química Orgânica, Instituto de Química, UNESP, Araraquara, SP, Brazil
4Departamento de Biologia Vegetal, Instituto de Biologia, UNICAMP, 13083-970 Campinas, SP, Brazil
5Departamento de Química Orgânica, Instituto de Química, UNICAMP, 13083-970 Campinas, SP, Brazil
6Faculdade de Farmácia, Universidade Santa Cecília, UNISANTA, Santos, SP, Brazil

Received 20 October 2011; Accepted 22 December 2011

Academic Editors: H. Liu, S. Mueller-Lissner, T. Ohkusa, and T. Yoshikawa

Copyright © 2012 Felipe Meira de-Faria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in adittion, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property.