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The Scientific World Journal
Volume 2012 (2012), Article ID 327341, 8 pages
http://dx.doi.org/10.1100/2012/327341
Review Article

Colorectal Cancer Chemoprevention: Is This the Future of Colorectal Cancer Prevention?

Oncology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain

Received 25 October 2011; Accepted 17 November 2011

Academic Editors: C. Bosetti and L. Roncucci

Copyright © 2012 A. Manzano and P. Pérez-Segura. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Colorectal cancer (CRC) is presently one of the most common causes of cancer-related death in our setting and affects a great number of people each year. Screening strategies are commonly used but they do not seem enough to avoid CRC development or prevent completely its mortality. Because of this fact other prevention strategies have gained interest in recent years. Chemoprevention seems to be an attractive option in this setting and several drugs have been studied in this field. This review is focused on salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs) and cycloxygenase-2 inhibitors (COXIBs), whose mechanism of action could be directly related to colon cancer chemoprevention.