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The Scientific World Journal
Volume 2012, Article ID 350826, 11 pages
http://dx.doi.org/10.1100/2012/350826
Review Article

Rottlerin and Cancer: Novel Evidence and Mechanisms

1Department of Physiology, University of Siena, Aldo Moro Street, 53100 Siena, Italy
2Department of Biology and Evolution, University of Ferrara, Luigi Borsari Street 46, 44100 Ferrara, Italy
3Department of Food and Nutrition, Kyung Hee University, Seoul 130-701, Republic of Korea

Received 9 October 2011; Accepted 14 November 2011

Academic Editors: R. M. Bukowski, A. Dricu, and T. K. Kwon

Copyright © 2012 E. Maioli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Because cancers are caused by deregulation of hundreds of genes, an ideal anticancer agent should target multiple gene products or signaling pathways simultaneously. Recently, extensive research has addressed the chemotherapeutic potential of plant-derived compounds. Among the ever-increasing list of naturally occurring anticancer agents, Rottlerin appears to have great potentiality for being used in chemotherapy because it affects several cell machineries involved in survival, apoptosis, autophagy, and invasion. The underlying mechanisms that have been described are diverse, and the final, cell-specific, Rottlerin outcome appears to result from a combination of signaling pathways at multiple levels. This paper seeks to summarize the multifocal signal modulatory properties of Rottlerin, which merit to be further exploited for successful prevention and treatment of cancer.