Research Article

Prognostic Value of Hepatocyte Growth Factor, Syndecan-1, and Osteopontin in Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance

Figure 3

Comparison of serum levels of osteopontin (OPN) in different phases of multiple myeloma and in monoclonal gammopathy of undetermined significance. Vertical axis: serum levels of osteopontin (OPN, OSTEOP, ng/mL). Horizontal axis: (A) multiple myeloma at the time of diagnosis, (B) multiple myeloma (MM) in relapse/progression, (C) remission phase multiple myeloma, (D) monoclonal gammopathy of undetermined significance (MGUS). The differences between active phase MM (A versus B) and remission phase myeloma and MGUS (C and D) were not statistically different. The difference between MM in relapse/progression and remission phase MM was not significant, either. Significant differences were found between MM at the time of diagnosis and remission phase myeloma (A versus C; M 123,1 versus 66,55 ng/mL, 𝑃 = 0 , 0 0 0 3 ), MM at the time of diagnosis and MGUS (A versus D; M 123,1 versus 52,485 ng/mL, 𝑃 < 0 , 0 0 0 1 ), and MM in relapse/progression and MGUS (B versus D; M 74,975 versus 52,485 ng/mL, 𝑃 = 0 , 0 0 0 1 ).
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