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The Scientific World Journal
Volume 2012, Article ID 361382, 14 pages
http://dx.doi.org/10.1100/2012/361382
Research Article

Antitumor and Immunopotentiating Activity of Polysaccharide PST001 Isolated from the Seed Kernel of Tamarindus indica: An In Vivo Study in Mice

1Laboratory of Biopharmaceuticals, Division of Cancer Research, Regional Cancer Centre, Trivandrum 695 011, India
2INFORMM, Universiti Sains Malaysia, Health Campus 16150 Kubang Kerian, Malaysia

Received 26 October 2011; Accepted 22 December 2011

Academic Editors: U. S. Gaipl, A. Greco, and E. Han

Copyright © 2012 S. R. Aravind et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [20 citations]

The following is the list of published articles that have cited the current article.

  • Sukant Garg, Thanchanok Muangman, He Huifu, Li Ling, Sunil C. Kaul, and Renu Wadhwa, “Bioactivities in the tamarind seed extracts: A preliminary study,” vol. 1929, pp. 020011, . View at Publisher · View at Google Scholar
  • Manu M. Joseph, S.R. Aravind, Suraj K. George, Sheeja Varghese, and T.T. Sreelekha, “A galactomannan polysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity,” Carbohydrate Polymers, vol. 98, no. 2, pp. 1466–1475, 2013. View at Publisher · View at Google Scholar
  • W. Nie, and A. M. Deters, “Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways,” Dermatology Research and Practice, vol. 2013, pp. 1–14, 2013. View at Publisher · View at Google Scholar
  • Farhadul Islam, Soby Ghosh, and Jahan Ara Khanam, “Antiproliferative and hepatoprotective activity of metabolites from Corynebacterium xerosis against Ehrlich Ascites Carcinoma cells,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, pp. S284–S292, 2014. View at Publisher · View at Google Scholar
  • Manu M. Joseph, S.R. Aravind, Suraj K. George, K. Raveendran Pillai, S. Mini, and T.T. Sreelekha, “Antitumor activity of galactoxyloglucan-gold nanoparticles against murine ascites and solid carcinoma,” Colloids and Surfaces B: Biointerfaces, vol. 116, pp. 219–227, 2014. View at Publisher · View at Google Scholar
  • S.R. Aravind, Manu M. Joseph, Suraj K. George, K.V. Dileep, Sheeja Varghese, Alphy Rose-James, Prabha Balaram, C. Sadasivan, and T.T. Sreelekha, “TRAIL-based tumor sensitizing galactoxyloglucan, a novel entity for targeting apoptotic machinery,” The International Journal of Biochemistry & Cell Biology, 2014. View at Publisher · View at Google Scholar
  • Manu M. Joseph, S. R. Aravind, Suraj K. George, K. Raveendran Pillai, S. Mini, and T. T. Sreelekha, “Galactoxyloglucan-Modified Nanocarriers of Doxorubicin for Improved Tumor-Targeted Drug Delivery with Minimal Toxicity,” Journal of Biomedical Nanotechnology, vol. 10, no. 11, pp. 3253–3268, 2014. View at Publisher · View at Google Scholar
  • Manu M. Joseph, S.R. Aravind, Suraj K. George, Raveendran K. Pillai, S. Mini, and T.T. Sreelekha, “Co-Encapsulation of Doxorubicin With Galactoxyloglucan Nanoparticles for Intracellular Tumor-Targeted Delivery in Murine Ascites and Solid Tumors,” Translational Oncology, vol. 7, no. 5, pp. 525–536, 2014. View at Publisher · View at Google Scholar
  • Dong Wang, Shu-Qing Sun, Wei-Zhen Wu, Shun-Liang Yang, and Jian-Ming Tan, “Characterization of a water-soluble polysaccharide from Boletus edulis and its antitumor and immunomodulatory activities on renal cancer in mice,” Carbohydrate Polymers, 2014. View at Publisher · View at Google Scholar
  • Manu M. Joseph, S.R. Aravind, Suraj K. George, K. Raveendran Pillai, S. Mini, and T.T. Sreelekha, “Anticancer activity of galactoxyloglucan polysaccharide–conjugated doxorubicin nanoparticles: mechanistic insights and interactome analysis,” European Journal of Pharmaceutics and Biopharmaceutics, 2015. View at Publisher · View at Google Scholar
  • Xiao-Lei Ma, Meng Meng, Li-Rong Han, Zheng Li, Xiao-Hong Cao, and Chun-Ling Wang, “Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa,” Chinese Journal of Natural Medicines, vol. 13, no. 12, pp. 906–914, 2015. View at Publisher · View at Google Scholar
  • Ma Xiao-Lei, Meng Meng, Han Li-Rong, Li Zheng, Cao Xiao-Hong, and Wang Chun-Ling, “Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa,” Chinese Journal Of Natural Medicines, vol. 13, no. 12, pp. 906–914, 2015. View at Publisher · View at Google Scholar
  • Farzaneh Atashrazm, Ray M. Lowenthal, Gregory M. Woods, Adele F. Holloway, and Joanne L. Dickinson, “Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential,” Marine Drugs, vol. 13, no. 4, pp. 2327–2346, 2015. View at Publisher · View at Google Scholar
  • Manu M. Joseph, Aswathy G., Manojkumar T.K., and Sreelekha T.T., “Galactoxyloglucan-Doxorubicin Nanoparticles Exerts Superior Cytotoxic Effects On Cancer Cells − A Mechanistic And In Silico Approach,” International Journal of Biological Macromolecules, 2016. View at Publisher · View at Google Scholar
  • Sitthiphong Soradech, Intira Petchtubtim, Jeerayu Thongdon-A, and Thanchanok Muangman, “Development of Wax-Incorporated Emulsion Gel Beads for the Encapsulation and Intragastric Floating Delivery of the Active Antioxidant from Tamarindus indica L.,” Molecules, vol. 21, no. 3, pp. 380, 2016. View at Publisher · View at Google Scholar
  • Manu M Joseph, Jyothi B Nair, Ramya N Adukkadan, Neethu Hari, Raveendran Pillai, Ananthakrishnan J Nair, Kaustabh Kumar Maiti, and Sreelekha Therakathinal T, “Exploration of Biogenic Nano-Chemobiotics Fabricated by Sliver Nanoparticle and Galactoxyloglucan with an Efficient Bio distribution in Solid Tumor Investigated by SERS Fingerprinting,” ACS Applied Materials & Interfaces, 2017. View at Publisher · View at Google Scholar
  • Rakesh Kumar Majhi, Chandan Goswami, Luna Goswami, Sridhar Sanyasi, Satish Kumar, Arijit Ghosh, Navneet Kaur, Priyanka Choudhury, and Udai P. Singh, “A Modified Polysaccharide-Based Hydrogel for Enhanced Osteogenic Maturation and Mineralization Independent of Differentiation Factors,” Macromolecular Bioscience, vol. 17, no. 3, 2017. View at Publisher · View at Google Scholar
  • Alphy Rose James, Bs Unnikrishnan, R Priya, Manu M Joseph, Tk Manojkumar, K Raveendran Pillai, R Shiji, Gu Preethi, P Kusumakumary, and Tt Sreelekha, “Computational and mechanistic studies on the effect of galactoxyloglucan: Imatinib nanoconjugate in imatinib resistant K562 cells,” Tumor Biology, vol. 39, no. 3, pp. 101042831769594, 2017. View at Publisher · View at Google Scholar
  • Maryam Burney, Lata Mathew, Anjali Gaikwad, Elizabeth K. Nugent, Anneliese O. Gonzalez, and Judith A. Smith, “ Evaluation Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus in Combination With Anticancer Drugs in Human Cancer Orthotopic Mouse Models ,” Integrative Cancer Therapies, pp. 153473541774063, 2017. View at Publisher · View at Google Scholar
  • Mohd Yasin Bhat, Mir Zahoor Gul, Radheshyam Maurya, Nooruddin Khan, Insaf Ahmed Qureshi, and Irfan Ahmad Ghazi, “ Growth Inhibition and Apoptosis Inducing Effects of Artemisia absinthium L. Fractions on Chronic Myeloid Leukemia (K562) Cells ,” Journal of Biologically Active Products from Nature, vol. 8, no. 2, pp. 70–89, 2018. View at Publisher · View at Google Scholar