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The Scientific World Journal
Volume 2012 (2012), Article ID 363296, 8 pages
http://dx.doi.org/10.1100/2012/363296
Clinical Study

Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis

1Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland
2Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, 79 Dabrowskiego Street, 60-529 Poznan, Poland

Received 10 October 2011; Accepted 2 November 2011

Academic Editors: B. B. Adams and C. Sitaru

Copyright © 2012 Justyna Gornowicz-Porowska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Dmochowski, “Dermatitis herpetiformis,” in Autoimmune Blistering Dermatoses, pp. 281–311, Scientific Publishing of Poznan University of Medical Sciences, Poznań, 2006. View at Google Scholar
  2. M. Duś, A. Dańczak-Pazdrowska, J. Gornowicz, M. Bowszyc-Dmochowska, and M. Dmochowski, “Transient manifestation of dermatitis herpetiformis in a female with familial predisposition induced by propafenone,” Advances in Dermatology and Allergology, vol. 26, no. 4, pp. 239–242, 2009. View at Google Scholar · View at Scopus
  3. J. J. Zone, “Skin manifestations of celiac disease,” in Proceedings of the NIH Consensus Development Conference on Celiac Disease, pp. 73–75, Bethesda, Md, USA, June 2004.
  4. T. L. Reunala, “Dermatitis herpetiformis,” Clinics in Dermatology, vol. 19, no. 6, pp. 728–736, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. S. M. Olbricht, T. J. Flotte, B. Collins, C. M. Chapman, and T. J. Harrist, “Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1,” Archives of Dermatology, vol. 122, no. 4, pp. 418–421, 1986. View at Google Scholar
  6. F. Wojnarowska, D. Delacroix, and P. Gengoux, “Cutaneous IgA subclasses in dermatitis herpetiformis and linear IgA disease,” Journal of Cutaneous Pathology, vol. 15, no. 5, pp. 272–275, 1988. View at Google Scholar · View at Scopus
  7. J. Gornowicz, M. Bowszyc-Dmochowska, and M. Dmochowski, “IgA antibodies against fusion protein containing modified nonapeptide of gliadin in dermatitis herpetiformis,” Dermatologia Kliniczna, vol. 12, no. 4, pp. 239–243, 2010. View at Google Scholar
  8. M. Sárdy, S. Kárpáti, B. Merkl, M. Paulsson, and N. Smyth, “Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis,” Journal of Experimental Medicine, vol. 195, no. 6, pp. 747–757, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Dieterich, E. Laag, L. Bruckner-Tuderman et al., “Antibodies to tissue transglutaminase as serologic markers in patients with dermatitis herpetiformis,” Journal of Investigative Dermatology, vol. 113, no. 1, pp. 133–136, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Gornowicz-Porowska, M. Bowszyc-Dmochowska, and M. Dmochowski, “Autoimmunity-driven enzymatic remodeling of the dermal-epidermal junction in bullous pemphigoid and dermatitis herpetiformis,” Autoimmunity, 2011. View at Publisher · View at Google Scholar
  11. E. Schwertz, F. Kahlenberg, U. Sack et al., “Serologic assay based on gliadin-related nonapeptides as a highly sensitive and specific diagnostic aid in celiac disease,” Clinical Chemistry, vol. 50, no. 12, pp. 2370–2375, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Sugai, E. Smecuol, S. Niveloni et al., “Celiac disease serology in dermatitis herpetiformis. Which is the best option for detecting gluten sensitivity?” Acta Gastroenterologica Latinoamericana, vol. 36, no. 4, pp. 197–201, 2006. View at Google Scholar · View at Scopus
  13. B. Wróblewska, A. Kaliszewska, E. Malinowska, and A. Troszyńska, “Immunoreactivity of transglutaminase cross-linked milk proteins in fermentem milk product obtained with Lactobacillus acidophilus,” Advances in Dermatology and Allergology, vol. 28, no. 4, pp. 261–267, 2011. View at Google Scholar
  14. M. Watanabe, J. Miyakawa, Z. Ikezawa, Y. Suzuki, and T. Hirao, “Production of hypoallergenic rice by enzymatic decomposition of constituent proteins,” Journal of Food Science, vol. 55, pp. 781–783, 2004. View at Google Scholar
  15. J. Leszczyńska, “Immunoreaktywność wybranych składników żywności i sposoby jej zmniejszania. (The methods of reducing immunoreactivity of the food allergens),” Scientific Notebooks, Dissertations/Technical University of Lodz, vol. Z 376, pp. 3–112, 2009. View at Google Scholar
  16. L. Lorand and R. M. Graham, “Transglutaminases: crosslinking enzymes with pleiotropic functions,” Nature Reviews Molecular Cell Biology, vol. 4, no. 2, pp. 140–156, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Zintzaras and A. E. Germenis, “Performance of antibodies against tissue transglutaminase for the diagnosis of celiac disease: meta-analysis,” Clinical and Vaccine Immunology, vol. 13, no. 2, pp. 187–192, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. O. Braun-Falco and H. H. Plewig, “Dermatitis herpetiformis,” in Dermatology T I, W. Giliński, H. Wolska, and P. Zaborowski, Eds., pp. 649–652, Czelej Publishing House, Lublin, 2002. View at Google Scholar
  19. C. Rose, E. B. Bröcker, and D. Zillikens, “Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis Duhring,” JDDG, vol. 8, no. 4, pp. 265–270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. C. M. Hull, M. Liddle, N. Hansen et al., “Elevation of IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis,” British Journal of Dermatology, vol. 159, no. 1, pp. 120–124, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Bowszyc-Dmochowska, A. Seraszek, E. Kaczmarek, J. Gornowicz, and M. Dmochowski, “Low strength of correlation between the level of serum IgA antibodies to epidermal transglutaminase and the intensity of neutrophil elastase expression in lesional skin in dermatitis herpetiformis,” The Open Autoimmunity Journal, vol. 1, pp. 1–4, 2009. View at Google Scholar · View at Scopus
  22. C. Rose, F. P. Armbruster, J. Ruppert, B. W. Igl, D. Zillikens, and I. Shimanovich, “Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet,” Journal of the American Academy of Dermatology, vol. 61, no. 1, pp. 39–43, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Kasperkiewicz, C. Dähnrich, C. Probst et al., “Novel assay for detecting celiac disease-associated autoantibodies in dermatitis herpetiformis using deamidated gliadin-analogous fusion peptides,” Journal of the American Academy of Dermatology, 2011. View at Google Scholar
  24. G. Byrne, F. Ryan, J. Jackson, C. Feighery, and J. Kelly, “Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding,” Gut, vol. 56, no. 3, pp. 336–341, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Fernández, S. Riestra, L. Rodrigo et al., “Comparison of six human anti-transglutaminase ELISA-tests in the diagnosis of celiac disease in the Saharawi population,” World Journal of Gastroenterology, vol. 11, no. 24, pp. 3762–3766, 2005. View at Google Scholar · View at Scopus
  26. E. Sugai, H. J. Hwang, H. Vázquez et al., “New serology assays can detect gluten sensitivity among enteropathy patients seronegative for anti-tissue transglutaminase,” Clinical Chemistry, vol. 56, no. 4, pp. 661–665, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. T. D. Jaskowski, M. R. Donaldson, C. M. Hull et al., “Novel screening assay performance in pediatric celiac disease and adult dermatitis herpetiformis,” Journal of Pediatric Gastroenterology and Nutrition, vol. 51, no. 1, pp. 19–23, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Martini, G. Mengozzi, G. Aimo, R. Pagni, and C. Sategna-Guidetti, “Diagnostic accuracies for Celiac disease of four tissue transglutaminase autoantibody tests using human antigen,” Clinical Chemistry, vol. 47, no. 9, pp. 1722–1725, 2001. View at Google Scholar · View at Scopus
  29. S. Vivas, J. M. Ruiz de Morales, J. Martínez et al., “Human recombinant anti-transglutaminase antibody testing is useful in the diagnosis of silent coeliac disease in a selected group of at-risk patients,” European Journal of Gastroenterology and Hepatology, vol. 15, no. 5, pp. 479–483, 2003. View at Publisher · View at Google Scholar
  30. J. F. Ludvigsson, B. Lindelöf, F. Zingone, and C. Ciamci, “Psoriasis in nationwide cohort study of patients with celiac disease,” Journal of Investigative Dermatology, vol. 131, pp. 2010–2016, 2011. View at Google Scholar
  31. M. Dmochowski, J. Gornowicz, A. Seraszek et al., “Cutaneous expression of neutrophil elastase in relation to IgA autoantibodies to nonapeptides of gliadin and tissue transglutaminase in dermatitis herpetiformis,” Journal of Investigative Dermatology, vol. 131, supplement 1, p. S2, 2011. View at Google Scholar
  32. S. Mihai and C. Sitaru, “Immunopathology and molecular diagnosis of autoimmune bullous diseases,” Journal of Cellular and Molecular Medicine, vol. 11, no. 3, pp. 462–481, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. J. J. Zone, L. A. Schmidt, T. B. Taylor et al., “Dermatitis herpetiformis sera or goat anti-transglutaminase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology,” Journal of Immunology, vol. 186, no. 7, pp. 4474–4480, 2011. View at Publisher · View at Google Scholar
  34. N. H. Petersen, P. N. Hansen, and G. Houen, “Fast and efficient characterization of an anti-gliadin monoclonal antibody epitope related to celiac disease using resin-bound peptides,” Journal of Immunological Methods, vol. 365, no. 1-2, pp. 174–182, 2011. View at Publisher · View at Google Scholar