The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer
Figure 3
Cytotoxicity in human cell lines induced by NK-1 receptor antagonists. An up-to-date outline of our so far published results is shown for the antitumor effect of NK-1 receptor antagonists (a) L-732,138, (b) L-733,060, and (c) aprepitant in a variety of human cell lines of different tissues including glioma, neuroblastoma, retinoblastoma, melanoma, carcinoma of pancreas, larynx, stomach, and colon. Concentrations of the antagonists are shown in μMolar for each cell line corresponding to 50 and 100 percent inhibition by cytotoxicity assay.
