Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012, Article ID 420190, 6 pages
Clinical Study

The rs2071559 AA VEGFR-2 Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients

1Ophthalmology Unit, University Hospital, Via Paradisa, 2-56124 Pisa, Italy
2Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55-56125 Pisa, Italy

Received 17 April 2012; Accepted 13 May 2012

Academic Editors: N. Bogdanova and S. Sivaprasad

Copyright © 2012 Stefano Lazzeri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this prospective, case-control genetic study, 120 consecutive neovascular age-related macular degeneration (AMD) cases and 78 controls were enrolled. Two SNPs (rs2071559 and rs1870377) of VEGF-A receptor-2 (VEGFR-2) gene were analyzed with the technique of Real-Time PCR to investigate a genetic link between AMD and VEGFR-2 gene polymorphisms in Italian patients. The frequency of the VEGFR-2 genotype rs2071559 AA was significantly lower (18.33%) in patients with AMD than in the control subjects (34.62%; 𝑃 = 0 . 0 0 9 5 , chi-square test; 𝑃 c o r r = 0 . 0 3 8 ; O R = 0 . 4 2 , 95% CI 0.22 to 0.82). In conclusion, although with the limitations of a small sample size and the few SNPs studied, this study demonstrates a lower frequency of VEGFR-2 rs2071559 AA genotype in an AMD patient population, suggesting future studies on the role VEGFR-2 SNPs.