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The Scientific World Journal
Volume 2012, Article ID 428979, 7 pages
http://dx.doi.org/10.1100/2012/428979
Research Article

Activated PTHLH Coupling Feedback Phosphoinositide to G-Protein Receptor Signal-Induced Cell Adhesion Network in Human Hepatocellular Carcinoma by Systems-Theoretic Analysis

1Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China
2Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, Beijing 100084, China

Received 11 June 2012; Accepted 29 July 2012

Academic Editors: S. Guleria and S. Yasmin

Copyright © 2012 Lin Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Hoshida, A. Villanueva, M. Kobayashi et al., “Gene expression in fixed tissues and outcome in hepatocellular carcinoma,” The New England Journal of Medicine, vol. 359, no. 19, pp. 1995–2004, 2008. View at Google Scholar
  2. R. Gianni-Barrera, M. Gariboldi, L. De Cecco, G. Manenti, and T. A. Dragani, “Specific gene expression profiles distinguish among functional allelic variants of the mouse Pthlh gene in transfected human cancer cells,” Oncogene, vol. 25, no. 32, pp. 4501–4504, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. D. W. Brandt, W. Wachsman, and L. J. Deftos, “Parathyroid hormone-like protein: alternative messenger RNA splicing pathways in human cancer cell lines,” Cancer Research, vol. 54, no. 3, pp. 850–853, 1994. View at Google Scholar · View at Scopus
  4. B. A. Miraliakbari, S. L. Asa, and S. F. Boudreau, “Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia,” Human Pathology, vol. 23, no. 8, pp. 884–887, 1992. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Loveridge, V. Dean, D. Goltzman, and G. N. Hendy, “Bioactivity of parathyroid hormone and parathyroid hormone-like peptide: agonist and antagonist activities of amino-terminal fragments as assessed by the cytochemical bioassay and in situ biochemistry,” Endocrinology, vol. 128, no. 4, pp. 1938–1946, 1991. View at Google Scholar · View at Scopus
  6. S. Kramer, F. H. Reynolds, M. Castillo, D. M. Valenzuela, M. Thorikay, and J. M. Sorvillo, “Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues,” Endocrinology, vol. 128, no. 4, pp. 1927–1937, 1991. View at Google Scholar · View at Scopus
  7. J. Henderson, M. Sebag, J. Rhim, D. Goltzman, and R. Kremer, “Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression,” Cancer Research, vol. 51, no. 24, pp. 6521–6528, 1991. View at Google Scholar · View at Scopus
  8. D. W. Brandt, D. W. Burton, A. F. Gazdar, H. E. Oie, and L. J. Deftos, “All major lung cancer cell types produce parathyroid hormone-like protein: heterogeneity assessed by high performance liquid chromatography,” Endocrinology, vol. 129, no. 5, pp. 2466–2470, 1991. View at Google Scholar · View at Scopus
  9. P. McAuley, S. L. Asa, B. Chiu, J. Henderson, D. Goltzman, and D. J. Drucker, “Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells,” Cancer, vol. 66, no. 9, pp. 1975–1979, 1990. View at Google Scholar · View at Scopus
  10. J. D. Storey, “A direct approach to false discovery rates,” Journal of the Royal Statistical Society B, vol. 64, no. 3, pp. 479–498, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Wang, T. Joshi, X. S. Zhang, D. Xu, and L. Chen, “Inferring gene regulatory networks from multiple microarray datasets,” Bioinformatics, vol. 22, no. 19, pp. 2413–2420, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Wang, Y. Sun, M. Jiang, and X. Zheng, “Integrative decomposition procedure and kappa statistics for the distinguished single molecular network construction and analysis,” Journal of Biomedicine and Biotechnology, vol. 2009, Article ID 726728, 6 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Wang, Y. Sun, M. Jiang, S. Zhang, and S. Wolfl, “FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis,” Cancer Investigation, vol. 27, no. 8, pp. 816–824, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Wang, L. Sun, J. Huang, and M. Jiang, “Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation,” Cell Proliferation, vol. 44, no. 3, pp. 291–299, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Wang, J. Huang, M. Jiang, and X. Zheng, “AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues,” Tumour Biology, vol. 31, no. 5, pp. 417–425, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Wang, J. Huang, M. Jiang, and L. Sun, “MYBPC1 computational phosphoprotein network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients,” Cellular and Molecular Neurobiology, vol. 31, no. 2, pp. 233–241, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Wang, J. Huang, M. Jiang, and L. Sun, “Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation,” Journal of Cellular Biochemistry, vol. 112, no. 5, pp. 1286–1294, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Wang, J. Huang, M. Jiang, and H. Lin, “Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation,” Journal of molecular neuroscience, vol. 47, no. 3, pp. 649–58, 2012. View at Google Scholar
  19. L. Wang, J. Huang, and M. Jiang, “RRM2 computational phosphoprotein network construction and analysis between no-tumor hepatitis/cirrhotic liver tissues and human hepatocellular carcinoma (HCC),” Cellular Physiology and Biochemistry, vol. 26, no. 3, pp. 303–310, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Wang, J. Huang, and M. Jiang, “CREB5 computational regulation network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients,” Cell Biochemistry and Biophysics, vol. 60, no. 3, pp. 199–207, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Sun, L. Wang, and L. Liu, “Integrative decomposition procedure and Kappa statistics set up ATF2 ion binding module in malignant pleural mesothelioma (MPM),” Frontiers of Electrical and Electronic Engineering in China, vol. 3, no. 4, pp. 381–387, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Sun, L. Wang, M. Jiang, J. Huang, Z. Liu, and S. Wolfl, “Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation,” Cell Biochemistry and Biophysics, vol. 56, no. 2, pp. 59–71, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Sun, L. Wang, M. Jiang, J. Huang, and H. Lin, “Glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) metabolism computational network analysis between chimpanzee and human left cerebrum,” Cell Biochemistry and Biophysics, vol. 61, no. 3, pp. 493–505, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. J. X. Huang, L. Wang, and M. H. Jiang, “TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients,” Journal of Inflammation, vol. 7, article 50, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Huang, L. Wang, M. Jiang, and X. Zheng, “Interferon α-inducible protein 27 computational network construction and comparison between the frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients,” Open Genomics Journal, vol. 3, no. 1, pp. 1–8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Mondal, K. K. Subramanian, J. Sakai, B. Bajrami, and H. R. Luo, “Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion,” Molecular Biology of the Cell, vol. 23, no. 7, pp. 1219–1230, 2012. View at Google Scholar
  27. J. L. Costantini, S. M. S. Cheung, S. Hou et al., “TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia,” Blood, vol. 114, no. 21, pp. 4703–4712, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. C. G. Kanakry, Z. Li, Y. Nakai, Y. Sei, and D. R. Weinberger, “Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/akt-dependent pathway: potential implications for schizoprenia and cancer,” PLoS ONE, vol. 2, no. 12, Article ID e1369, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. J. F. Wang, I. W. Park, and J. E. Groopman, “Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C,” Blood, vol. 95, no. 8, pp. 2505–2513, 2000. View at Google Scholar · View at Scopus
  30. F. Pellegatta, S. L. Chierchia, and M. R. Zocchi, “Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils,” Journal of Biological Chemistry, vol. 273, no. 43, pp. 27768–27771, 1998. View at Publisher · View at Google Scholar · View at Scopus