Activated PTHLH Coupling Feedback Phosphoinositide to G-Protein Receptor Signal-Induced Cell Adhesion Network in Human Hepatocellular Carcinoma by Systems-Theoretic Analysis

Table 1

(a) Biological processes and occurrence numbers of the same activated high expression (fold change ≥2) PTHLH feedback-mediated cell adhesion GO network in HCC compared with the corresponding low expression activated GO network of no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection), (b) the different compared with the corresponding inhibited PTHLH feedback-mediated cell adhesion GO network of no-tumor hepatitis/cirrhotic tissues, and (c) the same compared with the corresponding inhibited GO network of HCC by our programming.

(a) Biological process and occurrence number of GO term
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism	5
Cell adhesion	8
Cell differentiation	2
Cell-cell signaling	5
Endothelial cell migration	2
G-protein-coupled receptor protein signaling pathway	4
G-protein signaling	2
Intracellular transport	2
metabolism	4
Phosphoinositide-mediated signaling	4
Positive regulation of transcription	3
Protein amino acid phosphorylation	8
Regulation of cyclin-dependent protein kinase activity	8
Regulation of transcription	8
Signal transduction	10
Transcription	8
Transport	2
(b) Biological process and occurrence number of GO term
Integrin-mediated signaling pathway	2
Intracellular transport	2
Microtubule cytoskeleton organization and biogenesis	2
Regulation of cell growth	2
Regulation of cyclin-dependent protein kinase activity	8
(c) Biological process and occurrence number of GO term
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism	5
Cell adhesion	8
Cell differentiation	2
Cell-cell signaling	5
DNA repair	2
G-protein-coupled receptor protein signaling pathway	4
Integrin-mediated signaling pathway	2
Metabolism	4
Nucleotide and nucleic acid metabolism	2
Oxidation reduction	5
Phosphoinositide-mediated signaling	4
Positive regulation of transcription	3
Protein modification	2
Proteolysis	5
Regulation of cyclin-dependent protein kinase activity	8
Regulation of transcription	8
Signal transduction	10
Transcription	8
Transport	2