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The Scientific World Journal
Volume 2012 (2012), Article ID 435257, 12 pages
Review Article

A Review of Integration Strategies to Support Gene Regulatory Network Construction

Department of Medical Physiology, Texas A&M HSC College of Medicine, Temple, TX 76504, USA

Received 4 October 2012; Accepted 25 November 2012

Academic Editors: R. Jiang, W. Tian, J. Wan, and X. Zhao

Copyright © 2012 Hailin Chen and Vincent VanBuren. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gene regulatory network (GRN) construction is a central task of systems biology. Integration of different data sources to infer and construct GRNs is an important consideration for the success of this effort. In this paper, we will discuss distinctive strategies of data integration for GRN construction. Basically, the process of integration of different data sources is divided into two phases: the first phase is collection of the required data and the second phase is data processing with advanced algorithms to infer the GRNs. In this paper these two phases are called “structural integration” and “analytic integration,” respectively. Compared with the nonintegration strategies, the integration strategies perform quite well and have better agreement with the experimental evidence.