Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012 (2012), Article ID 465230, 11 pages
http://dx.doi.org/10.1100/2012/465230
Review Article

Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland

Received 30 January 2012; Accepted 16 February 2012

Academic Editors: F. Becq and A. De Roux

Copyright © 2012 Emer P. Reeves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [30 citations]

The following is the list of published articles that have cited the current article.

  • Gerald B. Pier, “The challenges and promises of new therapies for cystic fibrosis,” Journal of Experimental Medicine, vol. 209, no. 7, pp. 1235–1239, 2012. View at Publisher · View at Google Scholar
  • Simon Y. Graeber, Zhe Zhou-Suckow, Jolanthe Schatterny, Stephanie Hirtz, Richard C. Boucher, and Marcus A. Mall, “Hypertonic Saline Is Effective in the Prevention and Treatment of Mucus Obstruction, but Not Airway Inflammation, in Mice with Chronic Obstructive Lung Disease,” American Journal of Respiratory Cell and Molecular Biology, vol. 49, no. 3, pp. 410–417, 2013. View at Publisher · View at Google Scholar
  • Richard B. Moss, “Pitfalls of Drug Development: Lessons Learned from Trials of Denufosol in Cystic Fibrosis,” The Journal of Pediatrics, vol. 162, no. 4, pp. 676–680, 2013. View at Publisher · View at Google Scholar
  • Carole M. Liedtke, “Understanding the cellular mechanism for inhaled hyperosmotic saline therapy for patients with cystic fibrosis. Focus on "Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors",” American Journal of Physiology-Cell Physiology, vol. 305, no. 11, pp. C1096–C1097, 2013. View at Publisher · View at Google Scholar
  • Vignesh Venkatakrishnan, Nicolle H Packer, and Morten Thaysen-Andersen, “Host mucin glycosylation plays a role in bacterial adhesion in lungs of individuals with cystic fibrosis,” Expert Review of Respiratory Medicine, vol. 7, no. 5, pp. 553–576, 2013. View at Publisher · View at Google Scholar
  • Krisy-Ann Thornby, Ashley Johnson, and Samantha Axtell, “Dornase Alfa for Non-Cystic Fibrosis Pediatric Pulmonary Atelectasis,” Annals of Pharmacotherapy, vol. 48, no. 8, pp. 1040–1049, 2014. View at Publisher · View at Google Scholar
  • L. C. Huber, U. Buergi, M. M. Schuurmans, and C. Benden, “Non-cystic fibrosis bronchiectasis: diagnosis and treatment,” Deutsche Medizinische Wochenschrift, vol. 139, no. 34-35, pp. 1714–1720, 2014. View at Publisher · View at Google Scholar
  • Jennifer L Goralski, and Scott H Donaldson, “Hypertonic saline for cystic fibrosis: worth its salt?,” Expert Review of Respiratory Medicine, pp. 1–3, 2014. View at Publisher · View at Google Scholar
  • Anne-Laure Michon, Estelle Jumas-Bilak, Raphael Chiron, Brigitte Lamy, and Helene Marchandin, “Advances toward the Elucidation of Hypertonic Saline Effects on Pseudomonas aeruginosa from Cystic Fibrosis Patients,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Oliver J. McElvaney, Niamh O’Reilly, Michelle White, Noreen Lacey, Kerstin Pohl, Tanja Gerlza, David A. Bergin, Hilary Kerr, Cormac McCarthy, M. Emmet O’Brien, Tiziana Adage, Andreas J. Kungl, Emer P. Reeves, and Noel G. McElvaney, “The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis,” Molecular Immunology, 2014. View at Publisher · View at Google Scholar
  • Henry Goldstein, Andrew Tagg, Ben Lawton, and Tessa Davis, “Easing the wheeze,” Emergency Medicine Australasia, 2015. View at Publisher · View at Google Scholar
  • Guoshun Wang, and William M. Nauseef, “Salt, chloride, bleach, and innate host defense,” Journal Of Leukocyte Biology, vol. 98, no. 2, pp. 163–172, 2015. View at Publisher · View at Google Scholar
  • Ewa Tramś, and Dorota Sands, “Perspektywy leczenia przyczynowego mukowiscydozy,” Pediatria Polska, 2015. View at Publisher · View at Google Scholar
  • Anne-Laure Michon, and Hélène Marchandin, “Diversité physiopathologique du microbiote respiratoire,” Revue Francophone des Laboratoires, vol. 2015, no. 469, pp. 37–49, 2015. View at Publisher · View at Google Scholar
  • Jinghua Liu, Nancy M. Walker, Akifumi Ootani, Ashlee M. Strubberg, and Lane L. Clarke, “Defective goblet cell exocytosis contributes to murine cystic fibrosis–associated intestinal disease,” Journal of Clinical Investigation, 2015. View at Publisher · View at Google Scholar
  • Kristine Tanner, Shawn L. Nissen, Ray M. Merrill, Alison Miner, Ron W. Channell, Karla L. Miller, Mark Elstad, Katherine A. Kendall, and Nelson Roy, “Nebulized Isotonic Saline Improves Voice Production in Sjogren's Syndrome,” Laryngoscope, vol. 125, no. 10, pp. 2333–2340, 2015. View at Publisher · View at Google Scholar
  • Ravi Chopra, Lisa Paul, Rajapriya Manickam, Wilbert S Aronow, and George P Maguire, “Efficacy and adverse effects of drugs used to treat adult cystic fibrosis,” Expert Opinion on Drug Safety, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Daniel L. Hamilos, “Chronic Rhinosinusitis in Patients with Cystic Fibrosis,” The Journal of Allergy and Clinical Immunology: In Practice, vol. 4, no. 4, pp. 605–612, 2016. View at Publisher · View at Google Scholar
  • Eanna Forde, Andre Schuette, Emer Reeves, Catherine Greene, Hilary Humphreys, Marcus Mall, Deirdre Fitzgerald-Hughes, and Marc Devocelle, “Differential In Vitro and In Vivo Toxicities of Antimicrobial Peptide Prodrugs for Potential Use in Cystic Fibrosis,” Antimicrobial Agents And Chemotherapy, vol. 60, no. 5, pp. 2813–2821, 2016. View at Publisher · View at Google Scholar
  • Zahra Ezzeldin, Yasmeen Mansi, Mervat Gaber, Rania Zakaria, Rehab Fawzy, and Mohamed A. Mohamed, “Nebulized hypertonic saline to prevent ventilator associated pneumonia in premature infants, a randomized trial,” The Journal of Maternal-Fetal & Neonatal Medicine, pp. 1–6, 2017. View at Publisher · View at Google Scholar
  • Michael F. Papacostas, Peter Luckett, and Susan Hupp, “The use of pulmonary clearance medications in the acutely ill patient,” Expert Review of Respiratory Medicine, vol. 11, no. 10, pp. 815–826, 2017. View at Publisher · View at Google Scholar
  • Raffaella Nenna, Fabio Midulla, Caterina Lambiase, Giovanna De Castro, Anna Maria Zicari, Luciana Indinnimeo, Giuseppe Cimino, Patrizia Troiani, Serena Quattrucci, and Giancarlo Tancredi, “Effects of inhaled hypertonic (7%) saline on lung function test in preschool children with cystic fibrosis: results of a crossover, randomized clinical trial,” Italian Journal of Pediatrics, vol. 43, no. 1, 2017. View at Publisher · View at Google Scholar
  • Mario Mardirossian, Arianna Pompilio, Margherita Degasperi, Giulia Runti, Sabrina Pacor, Giovanni Di Bonaventura, and Marco Scocchi, “D-BMAP18 Antimicrobial Peptide Is Active In vitro, Resists to Pulmonary Proteases but Loses Its Activity in a Murine Model of Pseudomonas aeruginosa Lung Infection,” Frontiers in Chemistry, vol. 5, 2017. View at Publisher · View at Google Scholar
  • Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall, and David W. Parsons, “High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging,” Respiratory Research, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Changgong Li, Xiaofei Cong, Rolf D. Hubmayr, and Xiaoli Zhao, “Plasma membrane wounding and repair in pulmonary diseases,” American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 312, no. 3, pp. L371–L391, 2017. View at Publisher · View at Google Scholar
  • Till F. Kaireit, Sajoscha A. Sorrentino, Julius Renne, Christian Schoenfeld, Andreas Voskrebenzev, Marcel Gutberlet, Angela Schulz, Peter M. Jakob, Gesine Hansen, Frank Wacker, Tobias Welte, Burkhard Tümmler, and Jens Vogel-Claussen, “Functional lung MRI for regional monitoring of patients with cystic fibrosis,” Plos One, vol. 12, no. 12, pp. e0187483, 2017. View at Publisher · View at Google Scholar
  • Beatriz Santos-Carballal, Elena Fernández Fernández, and Francisco Goycoolea, “Chitosan in Non-Viral Gene Delivery: Role of Structure, Characterization Methods, and Insights in Cancer and Rare Diseases Therapies,” Polymers, vol. 10, no. 4, pp. 444, 2018. View at Publisher · View at Google Scholar
  • Seyed-Ahmad Tabatabaei, Gholamreza Panahandeh, Ghamartaj Khanbabaei, and Saeid Sadr, “The Acute Effect of Inhaled NaCl 5%, Per CF TRUST Protocol, on Spirometry Indices in Patients Over Six Years with Cystic Fibrosis,” Archives of Pediatric Infectious Diseases, vol. InPress, no. InPress, 2018. View at Publisher · View at Google Scholar
  • Ajantha Nadesalingam, Jacky H. K. Chen, Armin Farahvash, and Meraj A. Khan, “Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Susan E. Birket, Joy M. Davis, Courtney M. Fernandez, Katherine L. Tuggle, Ashley M. Oden, Kengyeh K. Chu, Guillermo J. Tearney, Michelle V. Fanucchi, Eric J. Sorscher, and Steven M. Rowe, “Development of an airway mucus defect in the cystic fibrosis rat,” JCI Insight, vol. 3, no. 1, 2018. View at Publisher · View at Google Scholar