Review Article

Pure Red Cell Aplasia and Lymphoproliferative Disorders: An Infrequent Association

Table 1

Classification of PRCA [2, 5].

Congenital PRCA
Primary autoimmune PRCA
Primary idiopathic PRCA
Secondary (acquired) PRCA, due to thymoma
Secondary PRCA, because of haematological malignancies (CLL, T-LGL/NK-LGL leukaemia, myeloma, NHL, MDS, ALL)
Secondary PRCA, related to infections (parvovirus B19, EBV, HIV, CMV, viral hepatitis, leishmaniasis, staphylococcemia)
Acquired PRCA, due to ABO-incompatible haematopoietic stem cell transplantation
Acquired PRCA, related to pregnancy
Secondary PRCA, because of autoimmune diseases (Sjögren’s syndrome, SLE, RA, mixed connective tissue disease, autoimmune hepatitis)
Secondary PRCA, because of previous treatment with recombinant human erythropoietin or other drugs (azathioprine, allopurinol, penicillin, linezolid, estrogens, ticlopidine, lamivudine, fludarabine)
Acquired PRCA, related to solid tumors (thyroid cancer, renal cell carcinoma)
Acquired PRCA, due to severe nutritional deficiencies