Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications
Figure 4
Gp120 induced a degradation of vascular basement membrane and vascular tight junctions. (a) After intra-CP injection of 500 ng gp120, fewer laminin- (a basement membrane protein) and occludin-(a tight junction protein) positive structures were seen. (b) Graph showing a significant reduction of laminin-, occludin-, and claudin-5-(another tight junction protein) positive structures in CPs injected with 500 ng gp120. Bar: (a) 60 μm.
