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The Scientific World Journal
Volume 2012, Article ID 498278, 11 pages
http://dx.doi.org/10.1100/2012/498278
Review Article

The Golgi in Cell Migration: Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis

1Department of Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany
2Biotechnology Institute Thurgau, Unterseestrasse 47, 8280 Kreuzlingen, Switzerland

Received 20 November 2011; Accepted 18 December 2011

Academic Editors: W. Bai, M. Chiariello, N. C. de Souza-Pinto, A. Dricu, and R. Hamamoto

Copyright © 2012 Valentina Millarte and Hesso Farhan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Migration and invasion are fundamental features of metastatic cancer cells. The Golgi apparatus, an organelle involved in posttranslational modification and sorting of proteins, is widely accepted to regulate directional cell migration. In addition, mounting evidence suggests that the Golgi is a hub for different signaling pathways. In this paper we will give an overview on how polarized secretion and microtubule nucleation at the Golgi regulate directional cell migration. We will review different signaling pathways that signal to and from the Golgi. Finally, we will discuss how these signaling pathways regulate the role of the Golgi in cell migration and invasion. We propose that by identifying regulators of the Golgi, we might be able to uncover unappreciated modulators of cell migration. Uncovering the regulatory network that orchestrates cell migration is of fundamental importance for the development of new therapeutic strategies against cancer cell metastasis.