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The Scientific World Journal
Volume 2012, Article ID 498489, 5 pages
http://dx.doi.org/10.1100/2012/498489
Research Article

The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain

1Department of Pharmacology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey
2Department of Physiology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey
3Department of Physiology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey
4Department of Histology and Embriology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey
5Department of Vocational School of Health Services, Celal Bayar University, 45030 Manisa, Turkey
6Department of Histology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey

Received 12 October 2011; Accepted 8 December 2011

Academic Editor: Eloisa Gitto

Copyright © 2012 Tuğba Gürpınar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.