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The Scientific World Journal
Volume 2012, Article ID 512047, 5 pages
Clinical Study

Auditing Clinical Outcomes after Introducing Off-Licence Prescribing of Atypical Antipsychotic Melperone for Patients with Treatment Refractory Schizophrenia

1Newham Centre for Mental Health, East London NHS Foundation Trust and University of Essex, London E13 8SP, UK
2Buckinghamshire NHS Primary Care Trust, Community Pharmacy, Aylesbury HP19 8ET, UK
3North East London NHS Foundation Trust, General Adult Psychiatry, Ilford, Essex IG3 8XJ, UK
4Kent and Medway NHS and Social Care Partnership Trust, Kent ME19 4AX, UK

Received 25 October 2011; Accepted 7 December 2011

Academic Editor: Serdar Murat Dursun

Copyright © 2012 Frank Röhricht et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims and Method. To evaluate the practical utility of off-licence prescribing and clinical outcomes of treatment with atypical antipsychotic Melperone. Method: Prospective data collection on patient’s clinical characteristics and outcomes. Results. 17 patients with a diagnosis of refractory schizophrenia were identified as suitable for off-license prescribing of Melperone and commenced treatment (13 were previously treated with Clozapine). Seven of those currently remain on Melperone (41%), and for six patents, the BPRS symptom scores reduced significantly over time (24–61%) additionally patients displayed improvements of their quality of life. Six patients were discontinued due to noncompliance and/or side effects. Melperone was ineffective in the other four patients. Clinical Implications. The example of a small group of patients responding well to a comparably safe and inexpensive atypical antipsychotic with favourable side effect profile should encourage clinicians to use this tool as third-line treatment and to conduct more systematic clinical research.