Research Article

Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice

Table 2

Hepatic granulomas of mice infected by S.mansoni and treated with LPSF/PT05-PEG.

Granuloma stagesControl3 mg/Kg10 mg/Kg30 mg/Kg100 mg/Kg

Exudative-productive 2 2 . 3 3 ± 4 . 1 6 1 5 . 6 6 ± 8 . 5 0 8 . 0 0 ± 1 . 7 0 * 2 0 . 6 6 ± 5 . 8 0 1 1 . 0 0 ± 1 . 0 0 *
Involutional 3 2 . 3 3 ± 1 2 . 5 0 4 3 . 3 3 ± 1 6 . 2 0 2 0 . 6 6 ± 7 . 7 6 4 4 . 0 0 ± 1 1 . 3 5 2 9 . 6 6 ± 9 . 2 9

Animals per groups ( 𝑛 = 5 ). The values are expressed in means ± SD. Comparisons were made by Student’s t-test (* 𝑃 0 . 0 5 ).