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The Scientific World Journal
Volume 2012, Article ID 537973, 8 pages
Research Article

Microstructure and Properties of Polyhydroxybutyrate-Chitosan-Nanohydroxyapatite Composite Scaffolds

Department of Electroceramics, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, Slovakia

Received 13 October 2011; Accepted 31 October 2011

Academic Editors: A. Bandyopadhyay and T. Ohura

Copyright © 2012 L. Medvecky. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Polyhydroxybutyrate-chitosan-hydroxyapatite (PHB-CHT-HAP) composite scaffolds were prepared by the precipitation of biopolymer-nanohydroxyapatite suspensions and following lyophilisation. The propylene carbonate and acetic acid were used as the polyhydroxybutyrate and chitosan solvents, respectively. The high porous microstructure was observed in composites and the macroporosity of scaffolds (pore sizes up to 100 μm) rose with the chitosan content. It was found the reduction in both the PHB melting (70°C) and thermal degradation temperatures of polyhydroxybutyrate and chitosan biopolymers in composites, which confirms the mutual ineraction between polymers and the decrease of PHB lamellar thickness. No preferential preconcentration of individual biopolymers was verified in composites, and the compressive strengths of macroporous PHB-CHT-HAP scaffolds were approximately 2.5 MPa. The high toxic fluorinated cosolvents were avoided from the preparation process.