Expressions of MMPs and TIMP-1 in Gastric Ulcers May Differentiate H. pylori-Infected from NSAID-Related Ulcers

Figure 1

The immunohistochemical stains for matrix metalloproteinase (MMP)-3, -7, and -9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in the Helicobacter pylori- (H. pylori-) infected group, in the nonsteroidal anti-inflammatory drug- (NSAID-) related group, and in the combined H. pylori-infection and NSAID-use group, in superficial epithelial cells and inflammatory cells of the lamina propria of gastric tissues (600x). H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers. Arrows indicate positive staining.