Effect of a Novel Nonviral Gene Delivery of BMP-2 on Bone Healing

Table 1

Investigated groups and timepoints of measurements.

Group	Implant	Analysis	2d	4d	7d	28d	42d
I	K-wire control (no coating)	(a) Biomechanical testing				𝑛=10	𝑛=10
		(b) Histology				𝑛=10	𝑛=10
II	+ PDLLA + copolymer	(a) Biomechanical testing				𝑛=10	𝑛=10
		(b) Histology				𝑛=10	𝑛=10
III	+ PDLLA + COPROG + BMP-2 (40 μg)	(a) Biomechanical testing				𝑛=10	𝑛=10
		(b) Histology				𝑛=10	𝑛=10
IV (safety)	+ PDLLA + COPROG + Luc (40 μg)	(c) Luciferase PCR	𝑛=5	𝑛=5	𝑛=5	𝑛=5	𝑛=5