Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication

Table 1

The effect of Mg supplementation on Zn, Cu, and Mg concentration in the urine of rabbits intoxicated with Cd.

				Days
	0	10	15	17	19	21	23	25	28
				Zinc (μmol/L)
Cd group^(1)	9.59±5.14	13.78±9.25	13.17±6.13	17.65±13.15	14.62±7.95	24.20±13.99^∗	23.00±14.89^∗	14.18±7.79	18.28±14.33
Cd + Mg group^(2)	10.69±2.90	10.75±5.78	16.81±8.88	15.04±9.26	14.19±5.73	16.03±8.83	15.73±3.37	10.71±4.76	15.69±6.41
				Copper (μmol/L)
Cd group	0.87±0.37	1.30±0.85	1.48±0.80	1.34±1.24	1.54±0.71^∗	2.16±1.07^∗∗	1.86±1.15^∗	1.74±1.12^∗	1.68±0.96 *
Cd + Mg group	0.89±0.55	1.19±0.63	1.14±0.80	1.21±1.00	1.10±0.69	0.99±0.60^†	1.08±0.32	1.12±0.41	1.22±0.52
				Magnesium (mmol/L)
Cd group	22.56±5.96	33.06±21.43	34.94±18.71	43.71±11.38^∗∗	36.55±13.75^∗	44.65±16.89^∗∗	44.53±15.48^∗∗	51.68±28.07^∗	48.95±24.42^∗
Cd + Mg group	23.59±5.70	54.14±26.49^∗∗∗†	60.96±25.44^∗∗∗†	74.85±22.37^∗∗∗††	77.75±27.61^∗∗∗†††	64.66±16.75^∗∗∗†	69.40±7.72^∗∗∗††	66.11±25.54^∗∗∗	60.98±27.92^∗∗∗

⁽¹⁾Cd group intoxicated orally every day for 4 weeks with 10 mg Cd/kg b.w.
⁽²⁾Cd + Mg group given 40 mg Mg/kg b.w. 1 h after Cd treatment.
Values are presented as the means ± SD. Marked values differ significantly (ANOVA + LSD test) from *control (day 0) and ^†Cd group.
^∗,†𝑃<0.05; ^{∗∗,††}𝑃<0.01; ^{∗∗∗,†††}𝑃<0.001.