Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication

Table 2

The effect of Mg supplementation on Zn, Cu, and Mg concentration in investigated tissues of rabbits intoxicated with Cd.

	Zinc concentration (μmol/kg)			Copper concentration (μmol/kg)			Magnesium concentration (mmol/kg)
	Controls^(1)	Cd group^(2)	Cd + Mg group^(3)	Controls	Cd group	Cd + Mg group	Controls	Cd group	Cd + Mg group
Heart	411.68±50.53	490.41±53.93	439.01±54.03	69.94±5.38	72.90±3.33	69.90±5.03	14.25±1.70	14.55±1.04	14.52±2.43
Lung	438.57±50.93	476.91±50.28	478.29±36.59	27.45±3.90	32.69±3.92	31.94±7.73	12.73±2.15	12.91±2.36	13.44±2.67
Liver	640.73±112.27	1037.02±128.61^∗∗	1023.23±178.61^∗∗	52.11±9.64	55.55±9.26	58.32±13.09	14.37±1.91	14.94±1.94	14.63±1.50
Kidney	677.15±106.09	825.39±178.96	717.80±80.52	55.07±8.58	74.88±11.37^∗	57.05±7.63^†††	14.19±2.87	14.99±3.12	14.62±1.80
Skeletal muscle	202.36±29.29	233.92±52.16	212.12±44.95	12.23±1.54	16.03±1.83^∗∗	13.65±2.45^†	25.84±2.12	21.48±2.44^∗	23.44±3.73
Brain	255.10±44.35	284.15±15.06	248.82±49.49	37.83±2.92	40.86±3.57	35.03±5.42^††	10.57±1.30	10.94±1.56	9.17±1.43^†
Pancreas	649.93±114.89	797.36±49.89	844.37±211.05^∗	15.05±2.81	19.34±3.68^∗	16.50±3.02	16.28±1.52	17.56±1.56	19.10±3.47
Spleen	435.44±91.35	591.04±103.48^∗∗	536.32±73.90^∗	32.53±3.87	38.08±4.23^∗	34.15±2.68	16.59±1.97	21.08±3.68^∗	17.14±3.64^†
Bone	3.75±0.42^(a)	2.61±0.32^∗(a)	2.55±0.35^∗(a)	199.65±34.67	201.74±40.27	190.71±26.44	343.46±22.31	340.34±20.41	341.94±25.43

⁽¹⁾Controls—nontreated animals.
⁽²⁾Cd group intoxicated orally every day for 4 weeks with 10 mg Cd/kg b.w.
⁽³⁾Cd + Mg group given 40 mg Mg/kg b.w. 1 h after Cd treatment.
Values are presented as the means ± SD. Marked values differ significantly (ANOVA + LSD test) from *control group and ^†Cd group.
^∗,†𝑃<0.05; ^{∗∗,††}𝑃<0.01; ^{∗∗,†††}𝑃<0.001.
^(a)mmol/kg.