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The Scientific World Journal
Volume 2012, Article ID 580216, 8 pages
Review Article

Influence of Healthcare-Associated Factors on the Efficacy of Hepatitis C Therapy

1Department of Medical Microbiology and Immunology, Faculty of Medicine, Tripoli CC 82664, Libya
2Department of Intervention Surgery, Faculty of Medicine, Tripoli CC 82664, Libya
3Department of Pharmacology, Faculty of Medical Technology, Al Jabal Al Gharbi University, Naloot, Gheraian, Libya

Received 3 October 2012; Accepted 25 November 2012

Academic Editors: T. Jehuda-Cohen and S. Unal

Copyright © 2012 Mohamed A. Daw et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatitis C infection is a complex entity associated with sizable morbidity and mortality, with great social and economic consequences that put a heavy potential burden on healthcare systems allover the world. Despite the great improvement of hepatitis C virus (HCV) therapy and its high clinical efficacy, major influencing factors are still hindering and diminishing the effectiveness of hepatitis C treatment. This minimizes the quality of life of the infected patients and reduces the outcome of such therapy, particularly in certain groups of patients such as intravenous drug users and patients coinfected with human immune deficiency virus (HIV). A variety of factors were evolved either at patient individual level, healthcare providers, community surrounding levels, or healthcare setting systems. Analyzing and understanding these factors could help to improve HCV interventions and, thus, reduce the burden of such infection. The objectives of this paper were to highlight such factors and outline the holistic approaches that could be used to overcome such factors.