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The Scientific World Journal
Volume 2012 (2012), Article ID 605610, 15 pages
Research Article

Robust Optimization of Alginate-Carbopol 940 Bead Formulations

1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, C/ Professor García González 2, 41012 Seville, Spain
2Department of Industrial Management, School of Engineering, University of Seville, C/ Camino de los Descubrimientos s/n, 41092 Seville, Spain

Received 31 October 2011; Accepted 8 December 2011

Academic Editor: Ali Nokhodchi

Copyright © 2012 J. M. López-Cacho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response under the point of view of the signal to noise ratio. A 𝐿18 Taguchi orthogonal array design was employed to investigate the effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related to drug release profile from beads (𝑡50% and AUC), swelling performance, encapsulation efficiency, shape and size parameters. Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the desired value.