Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis

Table 2

Animal studies: agents and model used in relation to the presented effect.

Impaired bone healing
(1) Aspirin [84]
(2) Celecoxib [101, 102]
(3) Diclofenac [97–99]
(4) Etodolac [104, 105]
(5) Ibuprofen [88, 94–96, 127]
(6) Indomethacin [78–91, 119, 127]
(7) Ketoprofen [77]
(8) Ketorolac [74–76, 107]
(9) Meloxicam [85, 103]
(10) Naproxen [92, 93]
(11) Parecoxib [74]
(12) Rofecoxib [92, 94, 95, 108, 109]
(13) Tenoxicam [99, 100]
(14) Valdecoxib [107]
No effect
(1) Celecoxib [80, 111, 119, 120]
(2) Diclofenac [123]
(3) Etoricoxib [110]
(4) Ibuprofen [111, 121, 122]
(5) Indomethacin [81, 111, 114–118]
(6) Ketoprofen [112, 113]
(7) Ketorolac [110, 111]
(8) Meloxicam [113]
(9) Nimesulid [124]
(10) Rofecoxib [111, 123, 125]
Short term has no effect
(1) Diclofenac [98, 106]
(2) Ketoprofen [126]
(3) Ketorolac [78]
(4) Parecoxib [106]
(5) Rofecoxib [85, 108]
(6) Valdecoxib [106]
Model used
(i) Rats; [74, 77, 78, 80, 81, 83, 84, 89–91, 93, 94, 97, 98, 100–107, 110, 114, 116, 118, 121–124, 126]
(ii) Mouse [109, 111, 120]
(iii) Rabbit; [75, 76, 79, 82, 85–88, 92, 95, 96, 99, 108, 112, 115, 119, 125]
(iv) Dog [117]
(v) Goats [113]